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As standard, mass specs have 3 components – a component to convert samples from liquid to gaseous form; a component to ionise the sample (hit with high energy to turn to positive or negative ions); and a component to detect quantities of each ion (peaks of each ion seen).

Instead of using a needle to aspirate and spray the samples as with standard mass specs, the acoustic mist ionisation mass spec (AMI-MS) sends a sonic pulse through liquid creating a ‘mountain of liquid on the surface’. For compound handling, a 2.5 nanolitre (nL) droplet is generated and fired from the liquid surface. For AMI-MS we send a second pulse through the mountain of liquid and this explodes the 2.5nL droplet into hundreds of femtolitre droplets. In effect sending a tornado of droplets through a charged field to generate a stream of ionised p文章s into the mass spectrometer.


LOL外围投注平台

LOL外围投注平台

LOL外围投注平台

LOL外围投注平台

LOL外围投注平台

LOL外围投注平台



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Jonathan Wingfield Principal Scientist, Discovery Sciences 电竞外围投注网址登录

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When you see the droplets flying and you see the science behind it – it’s astonishingly cool. It’s revolutionary. It allows us to work at very high throughput and with very small sample volumes – we only need 2nL of sample. Using this screening platform we can screen more compounds or more targets for the same cost. For some assays we could reduce the cost of High Throughput Screening by 80%.

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AstraZeneca has brought together a world leading supplier of mass spec technology (Waters) and the global leader in acoustic droplet ejection technology (Labcyte) to deliver this revolutionary platform. Having identified the opportunity, we took the idea to the partners, suggesting that it is possible to use acoustics in a different way in mass spectrometry. Being open about the work we are doing has shown the wider scientific community that we are prepared to invest in ground-breaking science; we are not just making a small change in mass spectrometry, but we are leading a potential revolution in mass spectrometry screening. We’re engaging the broader scientific community early in the process, and delivering real benefit to the community overall.

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The AMI-MS platform won the 2015 Innovation Award from the Society for Laboratory Automation and Screening. This is awarded to the podium presentation at the annual conference that shows the most innovation and impact in screening. We are the first non-US based company to receive this award.

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We recently published a paper on this technology in Analytical Chemistry with our collaborators at Waters and Labcyte: https://pubs.acs.org/doi/10.1021/acs.analchem.9b00142. Allowing us to reach a throughput of 100,000 samples per day on a single mass spec, we show that this technology – due to its speed, sensitivity, simplicity, robustness and consumption of nL volumes of sample – will have a major impact across many areas of basic and applied research.

When you see the droplets flying and you see the science behind it – it’s astonishingly cool. It’s revolutionary.

Jonathan Wingfield


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The best science doesn't happen in isolation.

We partner with others around the world, combining the great science in our labs with complementary technologies, know-how and molecules to accelerate the delivery of new life-changing medicines.


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